What Exactly is Lupus?


Our immune system is an incredible thing. It’s a complex, disease-fighting machine,
capable of fending off attacks from bacteria and viruses. But what happens when that same incredible
system stops fighting diseases, and starts attacking you? Lupus has been around for a very long time. Symptoms were first described back in the
nineteenth century, specifically a butterfly rash that appears on the face. It was later discovered that lupus causes
many, seemingly unrelated symptoms. But although we’ve known about the disease
for years, there’s still much about lupus we don’t fully understand. I’m Ali Duarte, I’m a physician and researcher. I’m also the co-director of the Lupus Program
here at Mayo Clinic in Rochester. Lupus is an autoimmune disease so this means
that your immune system that is in charge of defending you against microbes sort of
bacteria starts to attack itself. It’s, for example when you have a dog that
protects you against all the bad guys and then this dog starts to bite you. Autoimmune diseases aren’t uncommon, and there
are many different types. Even lupus has four variations. But for now, we’ll be focusing on this type,
systemic lupus. And that’s because… When people talk about lupus they’re usually
referring to systemic lupus the type of lupus that affects the internal organs. So, what would cause the immune system, or
the body’s guard dog, to turn against its owner? We don’t know. Which, is kind of the story behind lupus. There’s a lot we don’t understand. But, thanks to specialists like Dr. Duarte,
we know a lot more than we used to. So what do we know right now is or what we
think is that there is a genetic component and an environmental component. In order to begin to show the symptoms of
lupus, two things need to happen. First, since lupus isn’t contagious, you have
to have a genetic predisposition to the disease. The genetic factor that causes lupus is currently
unknown, but doctors do know that certain demographics are more at risk than others. So Lupus is a disease typically of young women. It affects a women 10 times more frequently
than males. And you usually see the disease between the
ages of 20 and 50. Because of the much higher rates of female
patients, researchers suspect that the disease is associated with the number of X-chromosomes
one has, since women have 2 x-chromosomes and men usually have only one. But simply having the genetic predisposition
is only the first part of the puzzle. And then if you were born with this a very
active immune system and you are exposed to the right stimuli which can be maybe a drug
or can be the UV light or something that we have any identified yet it starts and perpetuates
the disease. So what happens to your body when it encounters
a trigger? Well in lupus what happens is that something
like UV light may trigger cell death. So these cells start to die and they’d release
DNA and the DNA then is taken by one of the cells of the immune system called dendritic cells, and then these cells take the DNA and expose it and activate other cells called lymphocytes
so the T cells or the B cells. Normally, immune cells would just get rid
of a dead cell and move on. But in lupus patients, these cells are slow
at clearing the death cells and start to create an antibody against the cell’s DNA. Which is a big problem, because there are
a lot of healthy cells in your body that have that same DNA, which these immune cells now
want to destroy. This results in chronic inflammation and potentially
damage to internal organs like the kidneys or brain and can even lead to
organ failure and death. So even though we haven’t we haven’t had a
significant drug break through discoveries in the last 60 years we have learned how to
manage the disease better and in the last Just over half-a-century ago patients were
expected to live a few years Now, lifespans are close to average. Of course, there are still many unanswered
genetic questions. Lupus affects African Americans 3 to 4 times
more than caucasians, for example, and there is no identifiable genetic reason why this
should be the case. And while there is strong evidence that environmental
factors could be the culprit, the environmental triggers aren’t fully understood. So, while outcomes for patients diagnosed
with lupus are much better than they have ever been in the past, when it comes to exactly
how the disease works, the answer is still usually… We don’t know. So, while more women are at risk of developing
lupus than men, men tend to have worse outcomes. Like other aspects of the disease, this is
another unknown, but there are some theories… Maybe one of the components is just that males
take longer to go to the doctor and they may just delay going for looking for care so that
may change the prognosis of the disease So, maybe get a checkup every now and then, ok?

100 thoughts on “What Exactly is Lupus?

  1. Before this video: I believed that I had some basic knowledge about Lupus
    After this video: I just don't know anything about it.

  2. Yea boiiii I have Lupus and it BLOWSSSS
    Wouldn't wish it on my worst enemy lmao
    It's like…you get to live an almost normal life with medicine, but everything is worse and more difficult and will never be better, both physically with having red rashes and face swelling you have to try to cover up with green concealer so people don't ask if you've gotten in a fight, and all the joint pain from the arthritis doing normal tasks or exercise. Not to mention the sudden bouts of exhaustion lol.

  3. Ya but what treatments and solutions are we working towards? 1 out of how many people have it? How fatal is it?

  4. Maybe just maybe we should look into the environment! Now with 5G coming and still people are ignorant, time to wake up!

  5. Just to provide some education that whole thing about getting a check up every now and then is not very helpful when it comes to Lupus. Lupus often goes undiscovered because general practitioners don't know what to look for. The most common symptoms of Lupus, like chronic fatigue, are common in a great deal of illnesses , you have to go to a Rheumatologist to be diagnosed. I was hospitalized at 23 with terrible edema in my legs to the point I couldn't walk before I found out I was experiencing inflammation caused by Lupus. And moreover that it was life threatening because it was also attacking my kidneys.

  6. If males get worse outcome then it means its clearly due to exposure of an environmental factor.

  7. I think chimerism is behind it. We do know it's more common than previously thought.
    Going to the doctor more often won't help diagnose it. Most doctors don't look for autoimmune unless you specifically ask for it, even if all the symptoms have been there for years and years.

  8. is it opposite to cancer? cells here, die killing others along instead of proliferating snugly?

  9. Better content than usual you should let actual scientists do the talking. Your other pompous presentations are exceedingly obnoxious because you all try to sound smarter than you are.

  10. Better content than usual you should let actual scientists do the talking. Your other pompous presentations are exceedingly obnoxious because you all try to sound smarter than you are.

  11. Better content than usual you should let actual scientists do the talking. Your other pompous presentations are exceedingly obnoxious because you all try to sound smarter than you are.

  12. Better content than usual you should let actual scientists do the talking. Your other pompous presentations are exceedingly obnoxious because you all try to sound smarter than you are.

  13. I miss my auntie whom died earlier this year to lupus, 19 years she survived. I’m only 15 and I cannot imagine that pain, she would’ve won again but instead she was tired of fighting so we pulled it on her. I miss you everyday auntie, thank you vox for helping me understand this more than it’s understood itself

  14. The reason it’s more prominent in African Americans is probably air pollution, which is least likely to be dealt with by the government in their communities

  15. The premise of classic vaccine intervention is that a weakened virus is introduced into the body, causing the body's immune system to recognize this virus and respond through the production of antibodies. These antibodies, it is believed, will then protect the body from the real virus that comes along. It is the "rehearsal" model of immunology.

    This immunology model isn't wrong, but it also isn't complete. The body can only respond if its own immune system is sufficiently vigorous, and this comes primarily from good nutrition and behavioral choices. A junk food diet and chronic vitamin D deficiency, in other words, leads to chronic immune suppression. This causes vaccines to not work (not create the desired antibody response), and this simple truth is almost never reported by the mainstream media: Those who need vaccines the most are the least likely to benefit from them because their immune systems fail to generate the desired antibody response.

    Those with very strong, active immune systems, on the other hand, are very likely to naturally and automatically build their own antibodies to a real-world exposure to an invading viral strain. This often takes place asymptomatically (i.e. the person never even knows they "caught" the flu, because they never showed any symptoms). Thus, the people who are most likely to respond with antibodies to a vaccine are precisely the very same people who are least likely to need the vaccine (i.e. most likely to beat the flu on their own). This does not disregard the importance of vaccines in laboratory conditions, such as where scientists are working in level-4 biohazard labs, in which case they must obviously be fully vaccinated against those extremely deadly threats. However, even in such contexts, those scientists need to have healthy immune systems or they won't respond well to the vaccines.

    The vaccine industry response to this catch-22 by formulating vaccines with adjuvants — inflammatory chemicals designed to cause a heightened immune reaction so that those with weakened immune systems might generate some sort of antibody response. These chemicals and metals (including aluminum) are toxic to the body, which is why some small percentage of children receiving these vaccines experience devastating biological damage as a result (hence the Vaccine Injury Compensation Program).

    What the alternative health community really wants to see on vaccines — in my opinion, at least, but I think you'll find this to be a commonly held belief — is the elimination of all toxic chemicals and heavy metals from all vaccines. Mercury, aluminum, MSG, formaldehyde, etc. This would require vaccines to be offered in single-dose vials, not 10-dose vials as is currently the standard. We also want to see the vaccine industry educate doctors and health care providers of the importance of vitamin D used in conjunction with "clean vaccines." The vitamin D must be taken for many days in advance to build up vitamin D levels in the blood and activate the immune system gene expression. Only then can a clean vaccine produce the desired antibody response.

    Almost NONE of these issues are ever discussed in the mainstream media. The Atlantic is by far a more thoughtful, in-depth publication, which is why I'm hopeful that you will consider all that I've brought up here. The mainstream "tabloid" media attempts to paint this entire issue as "science vs. anti-science." It's nothing of the kind. So-called "anti-vaxxers" mostly aren't opposed to vaccines per se (although some are opposed to all such interventions, regardless of their composition); they are primarily opposed to the toxic elements formulated into those vaccines, and they are especially opposed to the totalitarianism mentality of the belligerent vaccine industry which leaves no room for intelligent questions, genuine scientific scrutiny or even any discussion of the removal of toxic elements from vaccines.

  16. Epigenetic’s are easy, just do a reset with the carnivore diet. Or you could chase your tail for money like these assholes.

  17. I have lupus symptoms but told I don’t have it. Yeah I’m male. Yeah I’m white, so yeah no it’s not lupus.

  18. Could you please cover LHON in your “Sick” series? I have Leber’s Hereditary Optic Neuropathy and it caused me to lose most of my sight when I was 16, I’m 24 now and I’m still confused about what happened in side my eyes.

  19. This is not correct i know people that have cured themselves from lupus by killing the fungus or viruses in the blood. Same with other autoimmune desease like arthritis. But lupus was the easiest to get rid of.

  20. Sick playlist is awesome plz make more videos ….I am a medical student it's very helpful to me and for medical student …. thanks

  21. They know. They just don't want to say. Vitamin deficiency is the #1 killer in the world. They won't say our food is what's killing us.

  22. I know what lupus is, a badass berserk mech than killed a mobile armor! Right? No? Ok, I’ll go now

  23. I remember in House MD lupus was often one of the guesses when diagnosing a patient but was there actually ever an episode when the patient did have lupus?

  24. Drinking all day animal ormones and eating protein designed for a complete type of body doesn’t help the immune system for shure , actually I think this confuse it … eat those veggies and beans avoid the animals and their derivates , this is my opinion

  25. I had no clue what Lupus was when I diagnosed! I have since learned, because learning about it is how you live with it.

  26. I think I have this crap. I've had this rash on my face for awhile. Ive had it before too, but they told me it was shingles.. smh. I'm getting nervous now.

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