Whack-a-Mole Medicine: David Sinclair’s Book LIFESPAN (Part 2)


Whack-a-mole medicine.
You’ve got your neurologist for your brain, your cardiologist for your heart,
nephrologist for your kidneys. And unfortunately, all of that’s completely
wrong. That’s what leads us into whack-a-mole medicine. This came… this is part 2 of a review on
David Sinclair’s new book, “Lifespan.” It’s I think in chapter 3, close to the end of
it, and he uses the term too. He didn’t create this term.
It’s something I’ve covered in other videos especially the videos for example
about TAME targeting aging with metformin. We’ll cover that again because
he talks about that as well in his book. Now here’s the thing. If you just deal
with cancer or heart attack or diabetes or COPD or stroke or heart failure, even
if you knock one of those out, you’re gonna knock… you’re gonna get killed by
others. Now there’s one point. You mentioned diabetes in here. If you’re
able to manage diabetes, you’re able to make a huge cut out of dementia, stroke,
heart attack. So there is a special consideration here for diabetes but
again let’s go back and look at the way medicines practiced right now. A doc gets
years and years worth of training on a specific disease or a specific organ
like the heart and they work hard to try to delay that the targeted diseases of
that organ like delaying again dementia. Dale Bredesen, he’s got a whole book
about delaying dementia. But again, let’s step back a second and talk about delay
the aging process. This is a cellular process, a molecular process. So once you
start delaying the aging process, you start wiping out all of it, delaying all
of these diseases. So that’s the focus of preventive medicine. That’s what I do and
I’m not the only one doing this again. And Sinclair is not the only
one talking about this. You see it with several people. We’ll talk about that in
just a minute. So again, as you begin to look at these diseases and look at
lifespan, age itself is the strongest risk factor for all of these chronic or
age-related disease. As you begin to dig deeper into the U.S.
statistics, you began to see. You know there’s a reason why we start talking
about chronic diseases starting at age 40. The actual molecular processes start
younger than that and that’s one of the unfortunate things about my practice. I
don’t get a lot of viewers in their 20s; I get a few. I don’t get a lot of
patients in their 20s; I get a few. But again, these molecular processes are
starting very very early. By the time we hit our 40s and 50s even without without
looking for it without knowing, anything about this process the molecular
processes of disease, we begin to notice things like plaque, chest pain, etc. So
again, just a quick comment about whack-a-mole medicine. That’s what it is.
I mentioned that David Sinclair’s not the only person talking about that. This
is Nir Barzilai on my upper left. I think it’s your upper left as well.
He’s the principal investigator for the TAME study – Targeting Aging
with Metformin. I’m gonna talk a little bit more about that in the next video on
the series. But Nir Barzilai has had to go to grappling with bureaucrats at the
National Institutes of Health for funding for TAME. Why? Because they’re
targeting aging with metformin. They’re not targeting a disease obviously. It
impacts a whole host of diseases. And guess what again. That’s been the major
cause of the delay at that important process, that important work The current
regulations still say in an NIH cannot classify aging as a disease and
therefore they can’t fund it. Another person that talks about this, he actually
uses a different term, you’ve heard his name before as well –
Valter Longo. So thank you very much for your interest. We’ll get into some other
concepts like the TaME study in other videos.
Take a minute, click the link below, you’ll find our membership page, all of
our digital products are there. Lots of free stuff too. Thanks.

14 thoughts on “Whack-a-Mole Medicine: David Sinclair’s Book LIFESPAN (Part 2)

  1. OK Doc, I get the concept but can anyone trained to treat the human body & all it's ailments be expected to diagnose & treat all conditions? That would mean being able to do all types of surgical procedures, i.e., open heart, intestinal, kidney, gall bladder, brain, spinal, orthopedic, and the list goes on…… Plus monitor & control many disease processes, both non-infectious & infectious, etc… So, what is the alternative that you would recommend? Perhaps I am not understanding your premise in detail? Thanks for your videos…………….

  2. I'd make the argument that if you can take care of diabetes you could manage parts of cancer too. You've said that before about tissue damage I have witnessed the tissue damage first hand. With alcoholism especially the repeated sugar dosing causes serious damage to tissue which in turn could lead to cancer. It's just easier to see with alcoholism then with twinkies.

  3. Brilliant, there are moments when I watch your videos and my brain has a minor happy explosion. On a related matter, Metformin and Sirtin1,…. a 2018 Spanish publication confirms the molecular role of Metformin in aging)

  4. NIH can't fund study for "aging"? Ok, so why don't we call it "age related diseases"? Makes me think of the Greek myth of Tithonus who was granted immortality but as a feeble old man. Aging per se is not the issue, but rather how we age. If as an 80 year old we could retain the youth and vitality of a 20 year old that would be something. Metformin btw is a intestinal antagonist. Those of us with IBS, IBD, Chron's are well advised to minimize Metformin if not skip it altogether.

  5. NIH can't fund study for "aging"? Ok, so why don't we call it "age related diseases"? Makes me think of the Greek myth of Tithonus who was granted immortality but as a feeble old man. Aging per se is not the issue, but rather how we age. If as an 80 year old we could retain the youth and vitality of a 20 year old that would be something. Metformin btw is a intestinal antagonist. Those of us with IBS, IBD, Chron's are well advised to minimize Metformin if not skip it altogether.

  6. Thank you so much for another insightful video. It is fair to say that it is coming to the forefront in medical science that if the hormone insulin can be kept in check then most of the other hormones will tend to follow suit. Therefore it has been said that insulin is the dominant hormone in the human body. I disagree, I am not sure if it is classified technically as a hormone, but I think dopamine is the dominant hormone. When you tell most humans something that they don't want to hear or something that depresses them they simply choose to not believe it. On the contrary when you tell them anything that makes them happy they have much more of a tendency to believe it. Eating carbs makes humans immediately feel good through the release of dopamine in the brain so they choose to believe it is the right thing to do. This creates the no win situation for medical professionals. Any human accomplishment starts in the mind. If i tell a friend they need to ditch the pizza, doughnuts, potatoes and rice they tell me where i can go; If a health care professional tells them the same thing they find another health care professional that will say, well… if you just don't eat a lot of it you will be o.k. All accomplishments start in the mind. I guess you can lead a human to water but you can't make him drink. lol Keep up the good work you are a blessing!

  7. I’m only on page 36 of Sinclair’s book and it’s too bad it’s not written for most of us lesser mortals who never studied organic or biochemistry. I’m pretty good at following complicated pathways but parts of this are challenging to keep up, especially without a good biochemical dictionary close by.

    Still trying to wrap my wits around SIRT1 to SIRT7, mTOR (mammalian target of rapamycin), etc. but will hang in there.

    Nice to see he addresses insulin and he does intermittent fasting. Can’t wait to see more on those. But WAS surprised to hear that he gets hungry when he does intermittent fasting. He must not be doing it correctly since the appetite hormones (leptin & ghrelin0 are suppressed when on low carb or keto. That’s why you now hear Keto being referred to as the “never hungry” diet. Hmm.

    But I’m going to hang in there to the end.

    Thanks for doing this book review Dr. Ford!

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