#TomorrowsDiscoveries: Chemotherapy-Resistant Breast Cancer Stem Cells – Dr. Gregg Semenza


[ Music ]>>Hi, I’m Gregg Semenza. I’m the Director of
the Vascular program in the Johns Hopkins
Institute for Cell Engineering. My laboratory is working
to develop new strategies to treat women with breast
cancer who require chemotherapy. Within a breast cancer,
a small population of cancer stem cells controls
tumor growth and metastasis. These cancer stem cells are
resistant to chemotherapy so that current treatments
may kill over 99% of the breast cancer cells but
leave behind cancer stem cells which can then give rise
to metastatic tumors later on that result in the death
of women with breast cancer. We’ve identified a way to
overcome the resistance of cancer stem cells to
chemotherapy which allows us to completely eradicate
breast tumors in mice. We plan to perform
additional studies to identify which particular chemotherapy
drugs are most effective in this strategy and then
to organize clinical trials to test whether this approach
will improve the survival of women with breast cancer. [ Music ]

1 thought on “#TomorrowsDiscoveries: Chemotherapy-Resistant Breast Cancer Stem Cells – Dr. Gregg Semenza

  1. It is said that the number of stem cells divisions in an organ is linked to the cancer probability for that organ
    and that this means that there are more natural chance DNA mutations the more a stem cell divides.
    I disagree strongly.When a stem cell divides it may be providing opportunities at division for carcinogens to
    interact with DNA bases so the more stem cell divisions the more chance a carcinogen has of causing trouble.
    Is there evidence that I am wrong about this?

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