Should 4 year old Poppy enter an NHS clinical trial?: Hospital Series 3 – BBC One


Poppy just became very sick. She fell.
Something just went “oh. There was a paranoia about brain tumours actually. So the shock that it was, it was like a complete unreality. My one question is, would she be eligible
for the study giving carboplatin? So we just need to have the final discussions with the family about the clinical trial. The next stage of treatment for Poppy is radiotherapy but she could be offered a
place on a new clinical trial involving a mix of radio and chemotherapy. In a clinical trial, you ask “This is the best treatment we think we know we have at
the moment… How can we do better?” And the only way you know when
you doing better or not, is to compare it with what’s the best so far. I don’t know
what’s best. If I knew what was best Poppy would be having it. That’s the
conversation we’ll need to have. And we will find out on Monday if we’ve been picked? If she’s even eligible to go into the trial. Yeah. Alright. Thank you
very much yeah. Pleasure. It’s no point thinking about it because we might not even get offered it yet and… we might talk ourselves into doing it and they say “Oh actually, you’re not eligible for it”. So you’ve made all that worry and stress… You can’t worry about something you don’t know is coming yet, you know? So, baby steps, isn’t it, Pops? Each day as it comes. Having children going on to clinical trials is important because we gain the experience and we gain the knowledge that that new
treatment brings. The lab tests on Poppy’s tumour are complete. They confirm that she is eligible to take part in the clinical trial. As an oncologist, you have
to be an optimist. We have been able to move the field forward. When I started
doing neuro-oncology, the cure rates were probably less than 50/50. We’re already at 70% and probably maybe higher that. Is it okay if I borrow your mummy and daddy for a little bit? The clinical trial will compare the impact of a mixed chemo and radiotherapy regime… I’ll see a little bit, okay? …against radiotherapy alone. If Poppy enters the trial, she’ll be randomly allocated a treatment.
The experimental regime may offer an increased chance of being cured but she
could also face additional side effects. The chemotherapy is what creates a
greater risk and you’re giving that on top of radiotherapy. It also can cause
mild kidney problems and mild hearing problems. Despite those side effects, the
benefits outweigh the disadvantages. Yeah. Sadly if Poppy recurred from
medulloblastoma, the chance of curing her a second time around would be
very small. So that’s why it’s important to accentuate and optimise the chance of
curing her first time round. Because we’re giving her all the best treatments
and once you’ve given those… …it’s very hard but in
order to cure her we have to accept that there is going to be some collateral
damage along the way. As to what’s the cure rate goes up by, I know that’s like asking what’s the winning lottery number type thing, isn’t it? It is a little bit but normally what you aim to achieve is at least a 10 to 20 percent
improvement and so on but… and it’s very hard to predict whether that’s going to be the case or not and that’s why you have to do this trial. This is a six months in
hopefully a very long life and it’s trying to make sure we make the best
decisions to get her to have that long life. It really is your decision. It’s quite
hard to have to make informed decisions as best they can with relatively little
information because this is all new territory to them. Is the right choice to
go into the trial or not to go to the trial? If they make a choice and Poppy
doesn’t do so well, have they made the wrong choice? It’s only as we’ve gathered more facts
and figures about it, that actually, okay yeah, that’s great. If that decision
improves Poppy’s prognosis and everyone else’s prognosis going forward, in the
view that this new treatment becomes the standard treatment, then we’ve got
to do it, haven’t we? Someone else selects which treatment
they get and that’s done by a computer to avoid any human interaction and any
prejudice over that process. I can’t choose, the parents can’t choose, my colleagues can’t choose. It’s taken out of our hands You alright, Poppy? So we’ve got the
randomisation result from the Clinical Trials Unit and Poppy’s drawn the
experimental arm so that’s the radiotherapy and the carboplatin. I see, okay. Right. Hello? Hello, it’s me. Erm… Professor Grundy’s just been. Yep. And Poppy has been chosen to do the experimental route. Oh god, has she? Yeah… so he’s just popped in to tell me. Are we good with that? Well yeah. We’ve got to go down one road, haven’t we? Yeah, and might as well go down the road that’s going to deliver better results hopefully. Going into an unknown is always daunting. We don’t know how Poppy is going to tolerate the
additional treatment but that’s the way we make progress. You’re on speaker, Steve, so I’ll… just say night night to Daddy, Poppy. Night night. Night night, Poppy. Love you. The idea is to improve the outcome for Poppy in all of
this and that’s what we’ll try and do and the NHS often rallies round in these
situations and let’s hope that’s gonna be the case. Say see you in the morning. See you in the morning. When the professors and the doctors
come to you with the plan, the solutions. The science and the medicine is at the end of the day, the thing that gives you hope.

10 thoughts on “Should 4 year old Poppy enter an NHS clinical trial?: Hospital Series 3 – BBC One

  1. Is this the girl that they wouldn't let leave Britain to get a special treatment in Spain or some shit?

  2. Following her story on Facebook- she’s doing very well!! Still having toxic chemo but she’s got no tumour ❤️❤️

  3. Hospital the murdering system, every drug on earth has a toxic in it along with all injections,  blatant murder of all who except their pills and needles of DEATH..

  4. Professer grundy is amazing he and other doctors/oncologists have been treating my cancer they are amazing including the nurses on e39

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