Endometriosis research at Warwick Medical School


I’m Erin Greaves, I’m an Assistant Professor
in the Division of Biomedical Sciences at Warwick Medical School. The Greaves Lab are doing research into endometriosis,
which is a chronic inflammatory disorder affecting one in ten reproductive age women. Endometriosis
is when tissue like the lining of the uterus, the endometrium, grows outside the uterus
– usually within the pelvic cavity. And this causes chronic debilitating pelvic pain
and infertility. Currently treatment options are limited to surgical removal of the lesions
or ovarian suppression. Both of these have unwanted side effects or
recurrence is a key problem. So immune cells called macrophages are present
in all tissues of the body and they’re also associated with lots of different diseases,
including endometriosis. In the Greaves Lab we’re investigating the role of macrophages
in endometriosis. We’ve found that they promote the growth of nerve fibres into lesions
and they play a key role in generating pain in the condition. Currently we’re trying
to investigate how many different types of macrophages are present in lesions, where
they come from and what they produce in order to try and identify a disease-promoting population. We hope to be able to understand macrophages
in endometriosis such that in the future they can be targeted therapeutically or modified.
Endometriosis affects 176 million women worldwide and we really hope that we can develop a treatment
that is non-invasive and non-hormonal and this will hopefully improve the lives of millions
of women.

10 thoughts on “Endometriosis research at Warwick Medical School

  1. The doctor and the patient are supposed to get red in the face but I suspect only I got red in the face this time… because here is not Dr. Gill! >:(

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