Dr. Eugene Kern’s (Mayo Clinic) Lecture on Empty Nose Syndrome (English)


This is just to let you know that the problem
is a real problem. This is mentioned in the International Rhinologic Society, the American
Rhinologic Society actually and the Mayo Clinic. We’ll be presenting “The Nose 2000 and Beyond”
in Washington DC September 20th to 23rd. The patients that I’m going to present,
uh… The patients that I’m gonna present – these patients are patients that I personally
have seen. Every single one of the cases in the 220 cases that I’m gonna review – I
have seen them personally in the 30 years, or 29 and a half years that I’ve been on
the staff of the Mayo Clinic. These patients represent a terrible problem.
Now, as I look out into the audience, I know a number of you, who do rhinology – have
you ever seen a patient who’s had this kind of CT scan and has had symptoms? You have?
What symptoms have they had? Stuffiness? The nose is wide open, but they have stuffiness.
What else? Crusting, drainage, malodor, nasal obstruction. Any pain? We’ll talk about
this. Because this is not an innocuous thing. And I’m passionate about it because I’ve
seen these patients, and I’m not making this up. And when I first heard about it – oh,
you can do a turbinectomy, there is no problem – I believed it, until I started seeing
the patients. And as Jean Vining was talking about, she sees the patients that come in,
and she allows 45 minutes to discuss this, and I do a little enactment, and I say the
patients look like this… Carrying X-rays and operative reports,
and they’re depressed. And when I look down the hall,
I know which patients are mine – they come in carrying all those
X-rays and operative reports and this is what the X-rays look like. I didn’t
make this up, this is what these X-rays look like. And almost all of them have the same
symptom complex. Difficulty breathing, crusting, bleeding, mucopurulent green-yellow discharge,
pain, a change in their sense of well-being and a good proportion of them are
depressed because of their chronic illness. I never thought that they would have
“protocoled” an emotional component to this, but now I know differently. It’s what we see.
So, I wanna present two cases very quickly, that I’ve seen personally, and I’ve had
to deal with this medically and emotionally. 54-year-old white woman. She’s complained
stuffiness in the nose since her cosmetic rhinoplasty 4 years earlier. She did have
a nasal injury in childhood. She also complained of a symptom of grogginess – we talked about
this at one of the tables over lunch yesterday. The inability to concentrate – have you
ever seen that in any of your patients? And that term that’s used in the medical literature
is aprosexia nasalis – inability to concentrate because of a nasal disorder. I’ve never heard
about that until probably about 15 years ago, and then I read about it, and it was first described
in Europe probably in the late 18th century – correction – late 17th century or early 18th century
by an autologist, Gilles of Amsterdam (Gilles de Amsterdam). Six months ago
she had a reconstructive procedure without any benefit, she had allergy treatment for
two years without any improvement, and here you can see – you can’t read this, I’m
sorry – but this is a psych evaluation. I sent the patient to psychiatry, and this
psychiatrist happens to have been an internist before he became a psychiatrist, and he described
her difficulty breathing as dyspnea and not anxiety-related – that’s what he said.
This patient committed suicide. And boy that got my attention. She committed suicide in
1988 and she warned me about it, and that’s why I sent her to the psychiatrist. Well, maybe
that’s just an odd thing that sometimes happens. Here’s the next patient that got my attention: 45 year old white male banker and farmer who
was from Iowa. Chief complaint – sinus problems. Had a nasal injury in childhood with
difficulty breathing after the injury. He had septal surgery – polypectomy – two years ago.
He developed the inability to concentrate, the grogginess, if you will, lethargy, irritability,
difficulty in breathing, he was treated with antibiotics and he was seen by me for evaluation,
I just put in a septal button cause he had a perforation. There’s was my operation
in 1993, he had a septal perforation and I slipped in a septal button.
And you see, it’s deceased. He committed suicide too, in 1994. In fact, I had to go to a deposition; this is
an announcement for me to come to a deposition. Because then you have to be asked: do you
take the turbinates out? And you’re challenged. How are you gonna answer that question? Cause
literature is replete with incidence of “it’s OK to do inferior turbinectomies.” So, I wanna
talk about the Empty Nose Syndrome very briefly – what I mean by that, what we mean by that,
and whether or not any of you have seen this, and if you do, how do we approach
the management practically. There’s just a few ideas I want to generate
here: one, is that the mucosa is the organ of the nose, it’s the organ of the nose,
that’s where everything happens. The four main functions of the nose are
olfaction, defense, respiration and cosmesis. That’s what I believe are the four main – four
primary functions of the nose. And whether it’s charging the inspired air with moisture
– that’s part of the respiratory function. Secretary IGA, IGG, mucociliary transport,
that’s all part of the defensive function. And so I just wanna show you at least the
thought that the mucosa is truly the organ of the nose and think of it – I suggest,
I offer to you for your consideration to please think of it, as an organ system. Just the
way you think of the lung or the liver, as organ systems, or the kidneys as organ systems.
And I’ll show you why in a moment. How much of the organ is left here? There’s not much
functioning mucosa left. It should have cilia. What do you think is here? This is much cilia.
I have a short video that we took in our laboratory, just to let you know what cilia looks like
if you haven’t seen it. And simple things, like neo-synephrine, can paralyze cilia. Jean
Vining talked about the study that was reported last year about hypertonic salt
can paralyze the cilia. I think we need to begin to think about the mucosa as the organ of the nose.
Here we see normal ciliary beat activity. You can see the brush borders here beating.
We now have methods to quantitate this. We can quantitate that using photometric methods,
photoelectronic methods. We can quantitate ciliary beat frequency. We think this is a
very important tool now, because we can apply topical solutions, various pharmacologic agents
and see what occurs to our normal ciliary beat frequency. And I want to show you some
normal cells again beating and that would generate that kind of response. It is easy
to see, it’s easy to see and now we have methods that we can quantitate the beating
of the cilia. So, when you’re removing all of this tissue, you’re removing functioning
ciliary mucosa. But here’s 0.5% solution applied. There’s no beat. You paralyze the cilia.
Just neo-synephrine, half percent neo-synephrine can paralyze the cilia. Many things can paralyze
the cilia, including hypertonic saline. So, I just suggest that we begin to think
about, when we put various preparations in the nose, what are we doing to the cilia,
what are we doing to the mucociliary transport. Even though we may not objectively be able
to reproduce that in our own offices, but ‘ut to have a concept of what’s occurring.
And second of all, when we remove functioning tissue, what happens? This is in a rabbit model, this
is the work of Judy Tria and Tom McCarthy in our lab, this is a rabbit preparation,
we drop some India ink and we started India ink studies yesterday. This is real time,
and look how the India ink is moved by ciliary activity towards the natural ostium of the
maxillary sinus in the rabbit preparation. We then infected the rabbit, and I think the
rabbit was sick for about six weeks – six to eight weeks. We induced chronic inflammatory
condition, and now we repeated the India ink study, so we dropped the India ink, and then
you see what happens in the infected situation. That’s another reason why if we spray something
in the nose, when the patient is already infected, we can’t expect that there’s gonna be
much mucociliary transport to get your medication to the site where you wanna get it to. That’s
one of the reasons we believe lavage, using both syringe and lavaging the cavity grossly,
is probably a better method to introduce medication into nasal cavities that are diseased.
So, those are just some ideas, if you will, that I think we should have in our mind about
this. And I mentioned the four important functions of the nose (at least I think they are important):
olfaction’s first, but then, for sure, defense and respiration, and then cosmesis. When we
destroy mucosa, injure mucosa, remove mucosa, these respiratory functions and defensive
functions can be significantly compromised. And the respiratory functions – we know
that wide open nose – when we convert a nose to a mouth, we make it wide open, it’s
not aerodynamically efficient, and we know from all of our patients’ and our own experience
with upper respiratory infections that mouth breathing is not satisfying.
It’s not satisfying. So, is it more satisfying to breathe through your nose or your mouth? Well, it’s more
satisfying to breathe through a normal nose that appears to have the narrow contours for
its respiratory function. Wide-open noses like this do not function for its respiratory
function, not to mention the defensive functional tissue being removed.
Now this is what we see in the literature: just take your scissors, and cut it out, and
throw it away. And there’s other things in the literature, many-many papers, I couldn’t
put them all in, but just talking about inferior turbinectomies, that it’s OK to do inferior
turbinate resections, total inferior turbinate resections, reduction of turbinates with lasers,
inferior or at least partial, now, turbinectomies. So here’s the second point. The first point
is that the mucosa is the organ of the nose. Here’s the second point: the functional
residual capacity of the nose. The question is: how much tissue can you remove and still
have normal function? We know you can remove probably 80 to 90 percent of a liver and still
have normal liver function. There’s a wide margin of safety as it were. We know you can
remove a kidney for sure and half of the second kidney and still have normal kidney function.
How much nose can we remove? I don’t think we know that. First of all, how many functional
tests do we have of nasal function that we use? Not many. So, we don’t know much about
the nasal function, at least its respiratory function and its defensive function, so it’s
really a guess. Second of all, the patients that I’ve seen – and I’ll briefly show
you the data – it took about six years for the nasal mucosa that was left behind to fail.
It took about six years for it to fail. So, once the nose is challenged after these procedures,
it takes time before the remaining tissue that’s left behind, the functioning residual
capacity of the nose to collapse and fail. So, that’s the second idea. Think about
what you leave behind. It’s not what you take, it’s what you leave behind that needs
to function, its respiratory function and defensive function for the future. Don’t
be a turbinator! That’s my message of the day: don’t be a turbinator. Cause how much
kidney can you remove, how much liver can you remove, how much nose can you remove –
that’s the question we each ask ourselves. I’ve done it, I’ve taken pieces out of the turbinates,
and I regretted it. So I’m just reporting to you what I’ve observed. And you have to base
your own decisions on your own experience and integrate that with the experience of
others. How does that saying go… “Good judgement comes from experience,
experience comes from bad judgement.” So, I’ve done lots of bad judgement.
Here’s another wonderful case: there’s your pre-op, post-op. And I’m not making
these up. These are cases of everyone, and these cases I’ve seen personally. There’s
another one. Nothing left. Look at this one. So how much of the nasal defense and respiratory
function is this one turbinate gonna do? It’s what the nose would look like. Actually it’s
the opposite side, it’s been cut off. That doesn’t look like healthy mucosa that’s
left. The other interesting thing is, I biopsied it. In the biopsy of what’s left, what we
see, is squamous metaplasia. That’s not respiratory epithelium anymore, it’s skin!
And so, you can’t have mucociliary transport any more, it’s gone! Squamous metaplasia
has occurred. And that helps me at least in thinking about how we’re gonna treat these patients.
How are we gonna treat these poor patients, who come in with crusting, bleeding,
difficulty breathing, inability to concentrate, difficulty sleeping, depression, and some
of them with the aprosexia. There’s another one: pre-op, post-op. Same patient. Septum’s straighter. There’s another one. And this is – I want to read this to you… … turbinates were resected. Excessive turbinate tissue removed can result in the Empty Nose Syndrome. And this patient had pain. And it’s almost
like a neurogenic pain. And I’ve spoken to anesthesiologists and neurologists about
the mechanisms of this amputation kind of pain. One pain that Dr. Vining was talking about
this morning after Caldwell-Luc, at least in few of the studies that I’ve read and some of
the patients that I’ve treated over the years, if they’ve had a Caldwell-Luc recently…
– Yes, but where’s the pain? – Well, pain’s in my face.
If it is unilateral it makes it much easier to say yeah oh where? Point with one finger
where it is up there? – It’s right here!
And then I usually block them, I take some xylocaine, I put some cetacaine in the
buccal gingival fold, let it sit for about 5 minutes just the way the dentists do, and I use a 30 gauge
needle, I’d put about a CC, I don’t necessarily go into the infraorbital foramen but in that region,
and the pain goes away. And I know it’s probably neurogenic pain secondary to the Caldwell-Luc.
And I usually send them to a pain clinic and they treat them with nortriptyline or consider blocks.
I think that helps determine whether or not there’s something going in the sinus, especially
if the CT is negative afterwards. It’s a neurogenic kind of pain. These patients have
a similar neurogenic amputation kind of pain. We call it the Empty Nose Syndrome of Sternquist.
This is Dr. Sternquist. These patients are nasal cripples. She’s in our laboratory
in 1994, she noticed the CT scans and she said: “Kernie, those X-rays look like they’re
empty! These patients have empty heads!” And so, that was born the Empty Nose Syndrome
of Sternquist. There, that’s the kind of X-ray we’re talking about. These patients have
crusting, bleeding, the foul odor because of the bacterial overgrowth, and the odour,
as a result of bacterial metabolism, recurrent infections, pain and depression.
Eric Moore, who is one of our residents, reviewed these patients. He did it
a few years ago, before he left his training. It’s in for publication in the American Journal of
Rhinology. These are all patients that I’ve seen, and 100% had crusting, 50% had some
type of emotional depression, 33% had epistaxis and anosmia. These are the features of
these nasal cripples, as we call them. And this was from non-malignant disease,
this is not the result of lateral rhinotomy or medial maxillectomy for inverting papilloma.
And these are patients that I’ve seen, I’ve asked for the old X-rays. Of the 222 we reviewed,
that’s what we see. Nasal obstruction, crusting, bleeding, recurring infections, pain, odour, dysosmia and
depression. And no matter how we cut it and how we slice it, these are the symptoms that
we see, and it took 6.1 years in Eric Moore’s study for those symptoms to become manifest,
for the functional residual tissue to fail. Be a conservative surgeon because the sequelae
can be serious. There it is. It’s what we’re seeing. Remember, if we biopsy this, you see
skin. There’s a little bit of cilia here on this specimen, but it’s mainly squamous
metaplasia. It’s skin in the nose now. No more respiratory epithelium.
So what do we do? This man had turbinectomy, what do we do? And that’s one of the places
I’ll use the topical Wilson’s solution, 80 mg of gentamicin in a liter of saline,
at least to try to wash out the debris because there’s no cilia on the skin obviously,
so you have to mechanically remove it. Second of all, systemic antibiotics I don’t believe
work as well, because you have to see, envision how it’s gonna get through the stroma, through
the basal membrane, through the skin and get out in high enough concentrations to affect
the bacteria that’s growing in the sinus cavities. So, remember, the skin is there,
and so, topical lavage I think is the corner stone of treatment along with support.
And sometimes we use some rose geranium, which is a preparation that has a pleasant odour,
cause frequently these patients complain of family members, or other people complain of
the odour. And the odour is really the saprophytes in the nose or the result of the bacterial
metabolism giving off its gases. So, you want to reduce the bacteria. So, we use Wilson’s
solution, 80 mg in the liter of saline, 80 mg of gentamicin, topical irrigations
to remove the bacteria. Sometimes when they say they can’t breathe,
we put cotton in their nose, right into their nasal valve angle, and sometimes
they’ll grab their chest. And I said: – Take a deep breath.
– Yeah, I can breathe now. And I’ve just seen it many times, and we’re
just trying to replace the resistors. I have some endonasal microplasty procedures, other
attempts that use hydroxylapatite. One of the colleagues in Europe is using hydroxylapatite,
and I’m thinking about a dozen or two dozen cases. Mucous membrane transplants don’t
work, at least not in my hands, and I’ve not used tissue expanders to try to produce
temporary resistance. The control of pain is difficult. We use 4% xylocaine in the sphenopalatine
ganglion and see if the pain goes away. I like to see the patients at the time of the pain,
and I spray their nose and put some 4% xylocaine on a cotton carrier into the sphenopalatine ganglion
and they say: “Yeah, yeah, the pain is better, the pain’s gone away.” Then I use phenyle,
and I learned this from Vernon-Grey about 25 years ago. I use 88% phenyle, you
dry it out, after you well anaesthetize the nose, and we’ve reported this in the literature
in, I think, 12 cases, 12 patients, and about 80% of them have control for at least
6 to 12 months. You’re trying to break the reflex arc.
If you can’t block the nose with 4% xylocaine, then we use nortriptyline, and I have the
pain clinic physicians manage that systemic use of nortriptyline. And so we’re still
in the process of analyzing that data. Conclusion: be a conservative surgeon, because
once you remove that tissue, it doesn’t regrow. I think I’ll conclude my talk at
this moment. Any questions? Yes, sir? Thank you. The question is with the new work being done
looking at ciliary activity, what do I think about that essentially, the evaluation of the various
preparations. I think it’s a long time coming, and I think we need to base our decisions
regarding what topical solutions and the concentrations and the preservatives that we’re going to
use based on objective evaluation of ciliary beat frequency. I mean it just makes sense.
I think that sometimes you’re forced to make a decision and the way I think about it,
the topical sprays aren’t gonna be as effective, if the cilia isn’t there – number
one. Number two – if there is a skin, then obviously the cilia isn’t there, because
there’s skin replacing the lining, so therefore I did washing. If you use a Waterpik or a bulb syringe,
it doesn’t matter to me, but removing the debris I think is a tremendous advantage for
the patient. The patients seem to benefit from that. But I think the future of course is:
all the things, that we put in the nose, we need to know, what it does
to the basic physiology. Yes, sir. The question is: what do I think
produces more damage – inferior turbinate or middle turbinate. From the patients that
I’ve seen this is purely anecdotal. I think the inferior turbinate, first of all,
it’s more tissue. So, if you think again, it’s an organ system. You’re removing a bigger
piece of the organ. And the interesting thing is, if you look later, you’ll see the middle
turbinate is trying to compensate. They’re trying to hypertrophy, to fill the air space,
to become, if you will, more physiologic. So, I think a large section of the inferior
turbinate removed is probably more deleterious. I think, and I didn’t show this data, but
we have now about, I think, 12 cases – somewhere in that magnitude, not very many –
patients, who did not have frontal disease. When they had their middle turbinates taken out,
and then subsequently they developed frontal disease. Has anyone seen that? Have you’ve seen it? You’ve seen it? You’ve seen it? OK. And what was your reason as to why that occurred? Synechia is one cause. The other cause that we speculated on is that the drying effect of the inspired air producing disturbance in ciliary function. Dryness is the death to cilia. Dryness is death to cilia. And then once the bacteria is there, if there’s no mucociliary transport to sweep it away, it certainly can obstruct that region and produce frontal sinusitis. Yes. I don’t know for sure. I just haven’t studied that. But, as a guess, probably I’d say, one or two hours. Does anyone have any information on that? Anyone? Help me? The question is, if you apply topical decongestant or anesthetic, say 0.5 % xylocaine,
and induce paresis on cilia, how long does it take
before normal ciliary beat recovers? Fully depends upon the agent. OK. So, it’s an area of interest, and we should try to
learn more, I should try to learn more about it. Yes.

5 thoughts on “Dr. Eugene Kern’s (Mayo Clinic) Lecture on Empty Nose Syndrome (English)

  1. This is a bunch of BULLSHIT!!!  What medical school did you go to and if so, where did you graduate in the class if you graduated?  I hear a lot of people are faking being doctors these days.  I need to look into your credentials sir!  What the Hell are you taking about?  It is most likely Perps attacking T.I's by always jamming tampons with bodily fluids up their nostrils.  That's what this so called dis-ease really is…just another made up illness like Fibromyalgia.  These people use Remote Neural Monitoring Devices…DISEASE…PERP's DISEASE is what it should be called.  The more tissue is probably due to the different sizes of tampons the Perps use and length of time of use.  And that is FREE advice and oh yeah…An apple a day, keeps the DOCTOR AWAY

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