Alzheimer’s Disease and Insulin Resistance: Is There a Connection?

You’re familiar with the trend of
calling cognitive decline, especially Alzheimer’s, type 3 diabetes, right? If not,
you should listen to this video. And even if you are, you might pick up a couple of
things. So let me just cover a couple of things really quickly. You know Dale Bredesen, in his book “The
End of Alzheimer’s,” he talks about a lot of different complicated things –
36 holes in the roof causing this problem. And so I attended his first
training session for doctors and he came up after the training session and asked
me what I thought, and I said, “I’m a little bit surprised. There was
very little information on insulin resistance and that’s at least half that
cause of cognitive decline, right?” He looked at me kind of funny and he said,
“Well, I think it’s a hundred percent the cause of Alzheimer’s. 80% are
known. The other percent, the rest of them, the following 20% are what we
call CNS insulin resistance.” Now what he was referring to is that there’s
actually a concept and there’s science behind it showing that you can
have a form of insulin resistance behind the brain blood-brain barrier in the CNS
(central nervous system). Now my view when I was hearing about that and when I’ve
talked about that before is that I think most of these people that have what’s
called CNS IR, you know they use the major… the most common ways of measuring
corporeal or a regular body IR (insulin resistance) and that is fasting blood
glucose and a hemoglobin A1c. As we know, that’s going to miss a huge number of
people that have IR (insulin resistance), prediabetes. So there’s a there’s quite
a few dots to connect here and again as often happens when these there’s so many
dots to connect, they’re not all fully understood. Number one, there’s clearly a
link between insulin resistance and dementia. 80% of folks have
not with dementia have with Alzheimer’s dementia have known insulin resistance or type
two diabetes. Of those that don’t, there’s clearly evidence within their brain that
they have insulin resistance. And again my perspective is in that 20%,
they just missed the rest of the insulin resistance. Now there’s something else
you need to note though. Insulin has a separate function within the brain
regarding memory and that may actually be one of the mechanisms that we don’t
talk a whole lot about. So they’ve done this, they’ve taken insulin and sprayed
it up into the nose that allows… the nose is an area where there’s just very
little tissue between the nose and the inside of the blood-brain barrier.
Insulin can actually go through that membrane. What happens is there are
several impacts of that insulin, many revolving around memory. Insulin has a
separate what we call pleiotropic or different type of role inside the brain
that’s focused on developing memory. And in fact, there are several different areas
within the brain that you have this impact. One of the key ones obviously
being at the hippocampus. The hippocampus is an area where it truly connects
the dots within the brain and in a person with Alzheimer’s, dementia,
sure enough we will see significant decrease in the mass of the hippocampus.
Nature magazine, you can’t get any better than that in terms of heart science, they
have a trend of labeling Alzheimer’s as “type 3 diabetes.” Now this gets into a
bunch of protein markers associated creating and documenting this
association between insulin resistance and diabetes. I’m not gonna go there,
that would get too geeky, you know that I tend to get geeky and enjoy that. But I’m
not gonna do that in this video. I just wanted to make the point that if you
don’t. if you haven’t heard of the link between insulin resistance and
Alzheimer’s. you should be thinking about it. Thank you for your interest.
My name is Ford Brewer. I started off as an ER doc then I became very
frustrated with the fact that most things that bring people into the ER
were preventable like heart attack and stroke. I went to John Hopkins to get
training and ended up running the program there in prevention. There, I
trained dozens of docs and again that was three decades ago. Since then, I’ve
trained thousands of docs and even more importantly supervised those docs. And
even most importantly, helped thousands of patients prevent things like heart
attack and stroke. Waiting for the disease and hoping for a cure for this
kind of devastation doesn’t work. So come to Louisville on November 8th and 9th.
We have a boot camp type of environment for two days where you learn all the
things that you didn’t learn from your doc in terms of heart attack stroke
prevention things like cardiovascular inflammation how to detect it, how to
measure things like insulin resistance (the number one cause of inflammation), how
to detect it, how to measure it, how to stop it, how to manage it. You also get
you can get the labs there for that event if you’d like and get a complete
evaluation. In addition, you get an arterial scan called a CIMT. To get the
right one of those is fairly difficult. So I’m looking forward to seeing you
there. Thanks.

13 thoughts on “Alzheimer’s Disease and Insulin Resistance: Is There a Connection?

  1. During the past 5 1/2 weeks I have seen a huge shift in fasting blood insulin levels and calculated HOMA-IR using a low carb/increased fat diet along with some breakfast skipping. Fasting insulin went from 12.7 to 7.9. Calculated HOMA-IR went from 2.88 to 1.74.

  2. Doc, can you please address inflammation produced by autoimmune disorders, and how you approach putting out those fires to benefit the heart? Millions out there would benefit.

  3. Interesting Doc! I knew that there was a connection but didn't realize how high the percentage was. Very eye opening. Thanks for your videos……………

  4. the connection is probably processed sugar and nitrite as a preservative
    that little tissue between the nose and inside the blood-brain barrier can be so thin for some people that it makes them sensitive to chemicals like mothballs and cleaning solutions

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